A comparative investigation of the nephrotoxic effects of various antihypertensive drugs in rats: Biochemical and histopathological analysis
ACTA MEDICA MEDITERRANEA, cilt.30, ss.515-521, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30
- Basım Tarihi: 2014
- Dergi Adı: ACTA MEDICA MEDITERRANEA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.515-521
- Anahtar Kelimeler: Antihypertensive agents, kidney, toxicity, rat, OXIDATIVE STRESS, KIDNEY, INFLAMMATION, ACCUMULATION, REPERFUSION, MIRTAZAPINE, INHIBITION, APOPTOSIS, ISCHEMIA, FIBROSIS
- Karadeniz Teknik Üniversitesi Adresli: Hayır
Özet
Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether clonidine, methyldopa, rilmenidine, amlodipine and ramipril establish nephrotoxic effects in rats.