A comparative investigation of the nephrotoxic effects of various antihypertensive drugs in rats: Biochemical and histopathological analysis

Malkoc I., Altunkaynak K., Turan M., Gursan N., Hacimuftuoglu A., Akcay F., ...Daha Fazla

ACTA MEDICA MEDITERRANEA, cilt.30, ss.515-521, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30
  • Basım Tarihi: 2014
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.515-521
  • Anahtar Kelimeler: Antihypertensive agents, kidney, toxicity, rat, OXIDATIVE STRESS, KIDNEY, INFLAMMATION, ACCUMULATION, REPERFUSION, MIRTAZAPINE, INHIBITION, APOPTOSIS, ISCHEMIA, FIBROSIS
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether clonidine, methyldopa, rilmenidine, amlodipine and ramipril establish nephrotoxic effects in rats.