A comparative investigation of the nephrotoxic effects of various antihypertensive drugs in rats: Biochemical and histopathological analysis

Malkoc I., Altunkaynak K., Turan M., Gursan N., Hacimuftuoglu A., Akcay F., ...More

ACTA MEDICA MEDITERRANEA, vol.30, pp.515-521, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2014
  • Journal Name: ACTA MEDICA MEDITERRANEA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.515-521
  • Keywords: Antihypertensive agents, kidney, toxicity, rat, OXIDATIVE STRESS, KIDNEY, INFLAMMATION, ACCUMULATION, REPERFUSION, MIRTAZAPINE, INHIBITION, APOPTOSIS, ISCHEMIA, FIBROSIS
  • Karadeniz Technical University Affiliated: No

Abstract

Aims: Hypertension is known to cause potentially fatal kidney damage. However, it is unclear whether long-term use of antihypertensive drugs establishes any toxic effect on the kidney. This study investigate whether clonidine, methyldopa, rilmenidine, amlodipine and ramipril establish nephrotoxic effects in rats.