Sepsis, also defined as systemic inflammatory response syndrome, is defined as life-threatening multi-organ dysfunction. Early diagnosis in severe bacterial infections such as sepsis, is very important for the treatment and control of infectious diseases. However, the basic problem in recognizing bacterial infections is that the signs and symptoms often overlap with the clinical symptom of other inflammatory disorders. Although microbiological, biochemical and molecular methods have been widely used in the diagnosis of infections, they have some limitations in terms of sensitivity and specificity. Therefore, a gold standard indicator has not been revealed yet. The proposed biomarkers should be determined by cost-effective, fast, simple, reliable, specific and sensitive methods. Presepsin is a new protein also known as soluble cluster of differentiation 14 (sCD14-ST) subtype. It regulates the cellular and humoral immune system by directly interacting with T and B cells. It increases in response to bacterial infections and decreases after antibiotic therapy. Therefore, it is considered as an indicator of activation of the immune cell response against an invading pathogen. It is also suggested that it may be an early biomarker for sepsis. 554 Presepsin has gained an important place in recent studies due to its stability in the general circulation and being a candidate biomarker of the first stage of systemic infection. The number of research articles and reviews about presepsin is increasing day by day in the literature. The purpose of this review is to evaluate the place and importance of presepsin measurement in sepsis, considering other sepsis biomarkers, which will provide great benefits to clinicians.