The additive effects of the number of staples and gluing on ultimate lateral resistance loads of surface-to-surface, multistaple- and glue-connected joints in oriented strandboards (OSB) were investigated. Experimental results indicated that for a stapled-glued OSB joint with a given configuration of surface-to-surface bonding area of two joint members, its ultimate lateral resistance load and stiffness are governed by the number of staples used and gluing, respectively. Applying glue to multistaple-connected OSB joints can alter the effect of the number of staples used on their ultimate lateral resistance loads. Gluing increases joint lateral resistance loads, but this increase will not be significant when the number of staples used reaches a critical number. Applying glue to a stapled OSB joint improves its stiffness when compared with the stiffness of a stapled-only joint. The differences in ultimate lateral resistance loads of stapled-glued joints among three OSB materials evaluated in this study were not significant when the number of staples was six or less, and the differences became significant when the number of staples increased to eight.