A RARE MUTATION IN EIF2B4 GENE IN AN EPILEPTIC CHILD WITH VANISHING WHITE MATTER DISEASE: A CASE REPORT

Gungor O., Ozkaya A. K., Hirfanoglu T., Dilber C., Aydin K.

GENETIC COUNSELING, cilt.26, sa.1, ss.41-46, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 1
  • Basım Tarihi: 2015
  • Dergi Adı: GENETIC COUNSELING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.41-46
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

A rare mutation in EIF2B4 gene in an epileptic child with vanishing white matter disease: a case report: A 12-month old boy presented with intractable seizures present since 3-month of age. He had, previously, been admitted numerous times to the pediatric emergency room for intractable and prolonged seizures during the course of his disease. Differential diagnosis was made to exclude several inborn metabolic disorders, including vitamin B6 deficiency, biotinidase deficiency and nonketotic hyperglycinemia. Although the initial brain MRI revealed a mild cerebral and cerebellar white matter involvement, follow-up images showed diffuse cerebral and cerebellar white matter dysmyelination, progressive rarefaction and cystic degeneration. A genetic analysis was performed for vanishing white matter (VWM) disease and a homozygote c.1091G>A mutation was detected at the EIF2B4 gene. This case emphasizes the fact that VWM disease may present with refractory seizures since early infancy.