The relation of the degree of left-hand preference to pattern reversal visual evoked potentials (VEPs) from right and left brain was studied in male left-handers. The degree of the left-hand preference was assessed by the Waterloo Handedness Questionaire. Visual stimuli consisted of black and white checkerboard patterns generated on a TV screen. VEPs were simultaneously recorded from occipital leads of the right and left hemispheres. The degree of left-preference was found to be inversely and significantly related to size of VEPs only from left brain, not from right brain. That is, the conduction time, amplitude, duration, and area of N1-P1 waves linearly decreased as the degree of left-hand preference increased. These results were in accord with the testosterone hypothesis of cerebral lateralization, but not compatible with the right shift theory of handedness. It was concluded that visuomotor control by the left brain would be the main biological correlate of left-hand preference with regard to sensori-motor and cognitive functions.