Objective: The aim of the present study was to evaluate the effects of the simplified ethanol-wet bonding technique and conventional water-wet bonding technique on short term nanoleakage within hybrid layers made with two different etch-and-rinse adhesives (Single Bond 2 and Prime & Bond NT). Materials and methods: Flat dentin surfaces from bovine incisors were prepared and finished with wet 600-grit abrasive papers, then divided into groups to be bonded with one of the adhesives. After etching and rinsing, dentin surfaces were either moistened with water (water-wet bonding technique) or moistened with absolute ethanol for 1 min (ethanol-wet bonding technique). Then, adhesives were applied, and composite buildups were done. Bonded teeth samples were sectioned into resin-dentin samples by means of a low speed diamond saw under water cooling. Specimens were immersed into a 50% (w/v) solution of silver ammoniacal nitrate for 18 h and exposed to photodeveloping solution for 6 h. The amount of silver nitrate uptake within the adhesive layer, or hybrid layer, was measured with energy dispersive spectroscopy (EDS) in different regions (n = 30). Results: Simplified ethanol-wet bonding significantly reduced nanoleakage within resin-dentin interfaces made with Single Bond 2 and Prime & Bond NT, but improvement at the nanoleakage of Single Bond 2 was only significant. Conclusion: Simplified ethanol-wet bonding may improve quality of hybrid layers made with commercially available simplified etch-and-rinse adhesives. But benefits of ethanol-wet bonding may depend on product.