Human has almost the same DNA sequences in an estimated 6 billion letters of code for their genome. There are slight differences between individuals. These differences, called genomic variants, occur at specific locations within DNA. These variants may be specific to that individual or may be in others. Some variants increase the risk of developing the disease, while others may reduce this risk. Researchers identify genomic variants associated with complex diseases by comparing the genomes of individuals with and without these diseases. Polygenic risk scores are used to estimate how collecting a person's variants affects their risk for a particular disease. In this study, scores were calculated by PRS analysis for a certain number of variants from the genetic data presented as Variant Call Format (VCF). PRS analysis can be performed with some software packages. However, PRS analysis for certain variants cannot be done with these software. For this reason, a software has been developed for PRS analysis. Thus, PRS analysis can be performed for the genetic variant list of interest. In this way, the contribution of certain genes to the disease can be examined separately or together, while the interactions of the genes with each other can be investigated using appropriate statistical methods.