Synthesis and antitumor activities of some new 4-(1-naphthylidenamino)- and 4-(1-naphthylmethylamino)-1,2,4-triazol-5-one derivatives


Demirbas N., Ugurluoglu R.

TURKISH JOURNAL OF CHEMISTRY, vol.28, no.6, pp.679-690, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2004
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.679-690

Abstract

A series of 4-(1-naphthylidenamino)-1,2,4-triazol-5-one derivatives (3a-e) were synthesized by condensation of corresponding 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 1-naphthaidehyde. Acetylation and alkylation of these compounds gave 4a-e and 5a-e, respectively. Sodium borohydride reduction of 1-naphthylidenamino derivatives afforded naphthylmethylamino derivatives. which were Subsequently acetylated. Depending on the duration of the acetylation. mono or bis acetamide derivatives were obtained.