Synthesis and antitumor activities of some new 4-(1-naphthylidenamino)- and 4-(1-naphthylmethylamino)-1,2,4-triazol-5-one derivatives


Demirbas N., Ugurluoglu R.

TURKISH JOURNAL OF CHEMISTRY, cilt.28, ss.679-690, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 28 Konu: 6
  • Basım Tarihi: 2004
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.679-690

Özet

A series of 4-(1-naphthylidenamino)-1,2,4-triazol-5-one derivatives (3a-e) were synthesized by condensation of corresponding 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 1-naphthaidehyde. Acetylation and alkylation of these compounds gave 4a-e and 5a-e, respectively. Sodium borohydride reduction of 1-naphthylidenamino derivatives afforded naphthylmethylamino derivatives. which were Subsequently acetylated. Depending on the duration of the acetylation. mono or bis acetamide derivatives were obtained.