Synthesis and antioxidant properties of some new 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazole derivatives


BEKİRCAN O. , Ozen T., Gumrukcuoglu N. , Bektas H.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, vol.63, no.5, pp.548-554, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1515/znb-2008-0512
  • Title of Journal : ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
  • Page Numbers: pp.548-554

Abstract

A series of new 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethyleneamino)-4H-1,2,4-triazole derivatives 3 were prepared in good yields by treatment of 4-amino-3-(4-chlorophenyl)-5-(pyridine-4-yl)-4H- 1,2,4-triazole (2) with selected aldehydes. Compounds 3 were reduced with NaBH(4) to afford the corresponding 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethylamino)-4H-1,2,4-triazole derivatives 4. Eighteen new compounds were synthesized and characterized by elemental analyses, IR. (1)H NMR and (13)C NMR spectral data. The compounds were screened for their antioxidant and antiradical activities.