Synthesis and antioxidant properties of some new 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazole derivatives

BEKİRCAN O., Ozen T., Gumrukcuoglu N., Bektas H.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, vol.63, no.5, pp.548-554, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1515/znb-2008-0512
  • Journal Name: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.548-554
  • Keywords: 4H-1,2,4-triazoles, 4-amino-4H-1,2,4-triazoles, 4-arylmethyleneamino-4H-1,2,4-triazoles, 4-arylmethylamino-4H-1,2,4-triazoles, antioxidant activity, ANTICONVULSANT ACTIVITY, SCHIFF-BASES, ACID, ANTIFUNGAL, ANTICANCER, 1,2,4-TRIAZOLES, ANTIBACTERIAL
  • Karadeniz Technical University Affiliated: Yes

Abstract

A series of new 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethyleneamino)-4H-1,2,4-triazole derivatives 3 were prepared in good yields by treatment of 4-amino-3-(4-chlorophenyl)-5-(pyridine-4-yl)-4H- 1,2,4-triazole (2) with selected aldehydes. Compounds 3 were reduced with NaBH(4) to afford the corresponding 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethylamino)-4H-1,2,4-triazole derivatives 4. Eighteen new compounds were synthesized and characterized by elemental analyses, IR. (1)H NMR and (13)C NMR spectral data. The compounds were screened for their antioxidant and antiradical activities.