Synthesis and antioxidant properties of some new 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazole derivatives

BEKİRCAN O., Ozen T., Gumrukcuoglu N., Bektas H.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, cilt.63, sa.5, ss.548-554, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1515/znb-2008-0512
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.548-554
  • Anahtar Kelimeler: 4H-1,2,4-triazoles, 4-amino-4H-1,2,4-triazoles, 4-arylmethyleneamino-4H-1,2,4-triazoles, 4-arylmethylamino-4H-1,2,4-triazoles, antioxidant activity, ANTICONVULSANT ACTIVITY, SCHIFF-BASES, ACID, ANTIFUNGAL, ANTICANCER, 1,2,4-TRIAZOLES, ANTIBACTERIAL
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

A series of new 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethyleneamino)-4H-1,2,4-triazole derivatives 3 were prepared in good yields by treatment of 4-amino-3-(4-chlorophenyl)-5-(pyridine-4-yl)-4H- 1,2,4-triazole (2) with selected aldehydes. Compounds 3 were reduced with NaBH(4) to afford the corresponding 3-(4-chlorophenyl)-5-(pyridin-4-yl)-4-(arylmethylamino)-4H-1,2,4-triazole derivatives 4. Eighteen new compounds were synthesized and characterized by elemental analyses, IR. (1)H NMR and (13)C NMR spectral data. The compounds were screened for their antioxidant and antiradical activities.