Synthesis, Characterization and Biological Activities of New Symmetric Bis-1,2,3-Triazoles with Click Chemistry


ÇELİK F. , ÜNVER Y. , Barut B. , ÖZEL A. , SANCAK K.

MEDICINAL CHEMISTRY, vol.14, no.3, pp.230-241, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.2174/1573406413666171120165226
  • Title of Journal : MEDICINAL CHEMISTRY
  • Page Numbers: pp.230-241
  • Keywords: 1,2,3-Triazole, anti-allergic, antimicrobial, antioxidant, click chemistry, enzyme inhibition, ANTIOXIDANT ACTIVITIES, IN-VITRO, MYCOBACTERIUM-TUBERCULOSIS, ANTIMICROBIAL AGENTS, ANTIFUNGAL ACTIVITY, POTENT INHIBITORS, CYCLOADDITION, 1,2,3-TRIAZOLES, DESIGN, RING

Abstract

Background: 1,2,3-Triazole and its derivatives have important biological activities such as antimicrobial, anti-allergic, analgesic, anti-HIV, antiinflammatory, anticancer, antimalarial and antituberculosis. Other significant triazole derivatives are 1,2,4-triazoles which play a very important role in the medicinal chemistry due to the antiinflammatory, antimicrobial, antimigraine, anticancer, antimicrobial and antimycotic activities. In this study, we aimed to synthesize a new series of bis-1,2,3-triazole derivatives including 1,2,4-triazole to obtain more effective biological activities.