Synthesis, Characterization and Biological Activities of New Symmetric Bis-1,2,3-Triazoles with Click Chemistry
MEDICINAL CHEMISTRY, cilt.14, sa.3, ss.230-241, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 3
- Basım Tarihi: 2018
- Doi Numarası: 10.2174/1573406413666171120165226
- Dergi Adı: MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.230-241
- Anahtar Kelimeler: 1,2,3-Triazole, anti-allergic, antimicrobial, antioxidant, click chemistry, enzyme inhibition, ANTIOXIDANT ACTIVITIES, IN-VITRO, MYCOBACTERIUM-TUBERCULOSIS, ANTIMICROBIAL AGENTS, ANTIFUNGAL ACTIVITY, POTENT INHIBITORS, CYCLOADDITION, 1,2,3-TRIAZOLES, DESIGN, RING
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Background: 1,2,3-Triazole and its derivatives have important biological activities such as antimicrobial, anti-allergic, analgesic, anti-HIV, antiinflammatory, anticancer, antimalarial and antituberculosis. Other significant triazole derivatives are 1,2,4-triazoles which play a very important role in the medicinal chemistry due to the antiinflammatory, antimicrobial, antimigraine, anticancer, antimicrobial and antimycotic activities. In this study, we aimed to synthesize a new series of bis-1,2,3-triazole derivatives including 1,2,4-triazole to obtain more effective biological activities.