Synthesis, Characterization and Biological Activities of New Symmetric Bis-1,2,3-Triazoles with Click Chemistry


ÇELİK F. , ÜNVER Y. , Barut B. , ÖZEL A. , SANCAK K.

MEDICINAL CHEMISTRY, cilt.14, sa.3, ss.230-241, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1573406413666171120165226
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.230-241

Özet

Background: 1,2,3-Triazole and its derivatives have important biological activities such as antimicrobial, anti-allergic, analgesic, anti-HIV, antiinflammatory, anticancer, antimalarial and antituberculosis. Other significant triazole derivatives are 1,2,4-triazoles which play a very important role in the medicinal chemistry due to the antiinflammatory, antimicrobial, antimigraine, anticancer, antimicrobial and antimycotic activities. In this study, we aimed to synthesize a new series of bis-1,2,3-triazole derivatives including 1,2,4-triazole to obtain more effective biological activities.