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JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.56, no.5, pp.1553-1559, 2019 (SCI-Expanded)
In this study, 4-{2-(2-thienyl)ethoxy}phthalonitrile (3) and its tetra substituted peripherally metal-free (4), lead (II) (5), magnesium (II) (6), and cobalt (II) (7) phthalocyanines were synthesized. The structural characterization of the obtained compounds was performed by a combination of FTIR, H-1-NMR, UV-vis, and MALDI-TOF techniques. The inhibitory properties of these compounds were determined using Ingkaninan's methods against cholinesterase enzymes. Compound (7) had the highest enzyme inhibitory effect toward AChE and BuChE enzymes with IC50 values of 23.71 +/- 0.39 and 27.29 +/- 0.22 mu M, respectively. The enzyme kinetic study of compound (7) demonstrated noncompetitive AChE inhibition and uncompetitive BuChE inhibition. The K-i values of compound (7) against AChE and BuChE were found to 39.15 and 7.25 mu M, respectively. In the tested compounds, (7) deserves further investigation for potential therapeutic candidates of Alzheimer's disease.