Risk Factors for Mortality Among Older Adults with Hospital-Acquired Bloodstream Infections in the Intensive Care Unit: A Multicenter Cohort Study

Hoffman T., Margalit I., Tabah A., Ruckly S., Barbier F., Singer P., ...More

INFECTIOUS DISEASES AND THERAPY, vol.14, no.2, pp.483-492, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2025
  • Doi Number: 10.1007/s40121-024-01104-z
  • Journal Name: INFECTIOUS DISEASES AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.483-492
  • Karadeniz Technical University Affiliated: No

Abstract

IntroductionWe aimed to investigate risk factors for mortality among older adults (>= 75 years) with hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU).MethodsWe included patients aged >= 75 years with HA-BSI in ICU from the EUROBACT-2 cohort (2019-2021). Univariable and multivariable analyses were conducted to identify predictors of 28-day mortality.ResultsThe cohort included 563 patients (median age 80, 39% women). Mortality at 28 day was 50%. Factors associated with mortality in multivariate analysis were admission due to COVID-19, failure to achieve source control, and higher SOFA. Among older adults with Gram-negative BSI, corticosteroid administration for septic shock was an additional factor. Among functionally independent patients, age itself was not associated with mortality.ConclusionsHA-BSI in older adults in ICU are associated with high mortality. Inadequate source control is a significant modifiable risk factor. The use of corticosteroids in ICU management of older adults should be further investigated.