Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): Enhancement of flap survival by EMLA

Karacal N., AMBARCIOGLU O., TOPAL U., MAMEDOV T., KUTLU N.

JOURNAL OF SURGICAL RESEARCH, vol.124, no.1, pp.134-138, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 124 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jss.2004.08.035
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.134-138
  • Keywords: EMLA, flap survival, random skin flap, LOCAL-ANESTHETICS, EUTECTIC MIXTURE, OINTMENT, NITROGLYCERIN, ABSORPTION, MODELS, AGENTS, CREAM
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background. Various topical pharmacologic agents have been investigated for their efficacy in preventing or reversing skin flap ischemia. Most of these studies have focused on agents that act on the vascular smooth muscles to cause vasodilatation and improve circulation in the flap. Most of local anesthetics relax vascular smooth muscle and produce peripheral vasodilatation. Topical lidocaine administration was shown that it was an effective and prompt resolution of mechanically induced vasospasm. The topical analgesia cream, EMLA is a mixture of the substances lidocaine and prilocaine. EMLA causes a biphasic vascular response comprising initial blanching and vasoconstriction (maximal after 1.5 h of application) and late erythema and vasodilatation at application times longer than 3 h.