Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): Enhancement of flap survival by EMLA

Karacal N., AMBARCIOGLU O., TOPAL U., MAMEDOV T., KUTLU N.

JOURNAL OF SURGICAL RESEARCH, cilt.124, sa.1, ss.134-138, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 124 Sayı: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jss.2004.08.035
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.134-138
  • Anahtar Kelimeler: EMLA, flap survival, random skin flap, LOCAL-ANESTHETICS, EUTECTIC MIXTURE, OINTMENT, NITROGLYCERIN, ABSORPTION, MODELS, AGENTS, CREAM
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background. Various topical pharmacologic agents have been investigated for their efficacy in preventing or reversing skin flap ischemia. Most of these studies have focused on agents that act on the vascular smooth muscles to cause vasodilatation and improve circulation in the flap. Most of local anesthetics relax vascular smooth muscle and produce peripheral vasodilatation. Topical lidocaine administration was shown that it was an effective and prompt resolution of mechanically induced vasospasm. The topical analgesia cream, EMLA is a mixture of the substances lidocaine and prilocaine. EMLA causes a biphasic vascular response comprising initial blanching and vasoconstriction (maximal after 1.5 h of application) and late erythema and vasodilatation at application times longer than 3 h.