Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF- κB axis and endoplasmic reticulum stress


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Demir S., Kazaz I. O., Kerimoglu G., Alemdar N. T., Colak F., Arici T., ...More

REVISTA INTERNACIONAL DE ANDROLOGIA, vol.22, no.1, pp.1-7, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.22514/j.androl.2024.001
  • Journal Name: REVISTA INTERNACIONAL DE ANDROLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE, DIALNET
  • Page Numbers: pp.1-7
  • Keywords: Apoptosis, Endoplasmic reticulum stress, Gallic acid, Inflammation, Oxidative stress, Testicular torsion
  • Karadeniz Technical University Affiliated: Yes

Abstract

It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2 '-deoxyguanosine, superoxide dismutase, catalase, high mobility group box 1 protein, nuclear factor kappa B, tumor necrosis factoralpha, interleukin-6, myeloperoxidase, 78-kDa glucose-regulated protein, activating transcription factor 6, CCAAT-enhancer-binding protein homologous protein and caspase-3 levels were determined using colorimetric methods. The oxidative stress, inflammation, endoplasmic reticulum stress and apoptosis levels increased statistically significantly in the IRI group compared with the sham operated group (p < 0.05). GA application improved these damage significantly (p < 0.05). Moreover, it was found that the results of histological examinations supported the biochemical results to a statistically significant extent. Our findings suggested that GA may be evaluated as a protective agent against testicular IRI.