Modern medical breakthroughs and general improvements in environmental and social conditions have raised the global life expectancy. As the world's population is aging, the incidence and prevalence of chronic diseases increases. Dramatic increase in the numbers of chronically ill patients is profoundly affects the healthcare system. Care at home provides benefits not only to patients but also the community and the health care providers. A telemedicine system utilizing today's information and mobile communication technologies plays a crucial role in providing care at home. Currently, diverse telemedicine projects are progress in the most countries. A telemedicine project is supported by The Scientific and Technological Research Council of Turkey (TOBITAK) under Grant 114E452 in Turkey. This project aims end to end remote monitoring of patients with chronic diseases such as heart failure, diabetes, asthma, and high blood pressure. A clinical decision support system integrated to telemedicine improves prognosis and quality of life in patients. The mainstay of a decision support system is early detection of important clinical signs and prompts medical intervention. Cardiovascular diseases are the leading cause of death globally. People with cardiovascular disease need early detection. An effective decision support system is needed to detect ECG arrhythmia before a serious heart failure occurs. One of the aims of the project is to develop decision support system which will detect whether a beat is normal or arrhythmia.