Simple and Fast Determination of Terbinafine in Human Urine by Dilute and Shoot HPLC-DAD Using a Core-Shell Column


YILDIRIM S., Demirdas G., Fidan M., YAŞAR A.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol.24, no.3, pp.342-351, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.2174/1386207323666200709171504
  • Journal Name: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.342-351
  • Keywords: Core-shell columns, dilute and shoot approach, fast analysis, high-performance liquid chromatography, terbinafinue rine, PERFORMANCE LIQUID-CHROMATOGRAPHY, LC-MS/MS ASSAY, HUMAN PLASMA, QUANTITATIVE-ANALYSIS, MASS-SPECTROMETRY, QUANTIFICATION, EXTRACTION, SPIRONOLACTONE, METABOLITES, VALIDATION
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: Terbinafine is an allylamine antifungal that is effective against many fungi, dermatophytes and moulds. Analytical methods are required for the determination of terbinafine in biological fluids to perform therapeutic drug monitoring and pharmacokinetic studies.