OXIDATIVE STRESS AND SERUM S100B LEVELS IN ADOLESCENTS WITH FIRST-EPISODE DRUG-NAIVE UNIPOLAR DEPRESSION

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BİLGİNER S. Ç., YAMAN H., Karadeniz S., Bulut S. H., Yaman S. O., AYDOĞDU S.

PSYCHIATRIA DANUBINA, vol.33, no.2, pp.158-164, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.24869/psyd.2021.158
  • Journal Name: PSYCHIATRIA DANUBINA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE, MEDLINE, Psycinfo, Social services abstracts
  • Page Numbers: pp.158-164
  • Keywords: unipolar depression, adolescent, SlOOB, oxidative stress, gender, MAJOR DEPRESSION, CHILD, DISORDER, EPISODES, SUPPORT, GENDER, SCALE
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: Unipolar depression is common among adolescents and has high recurrence rates. Studies conducted with adults show that oxidative stress plays a role in etiology of depression but studies with adolescent patients are limited. In addition, baseline S100B level in adult patients with depression is considered as a marker of response to treatment. The purpose of this study was to measure the levels of serum S100B, Malondialdehyde (DA), total oxidant status (TOS), and total antioxidant status (TAS), which have not been previously investigated in adolescent patients with first-episode, drug-naive unipolar depression, and to investigate the relationship of these parameters with disease severity and patient-specific variables.