We aimed to investigate if orbital dysmorphisms were more common in patients with long-standing and advanced nasal polyposis. A total of 42 nasal polyposis patients and 55 healthy controls were enrolled in this study. The distances between medial and lateral canthi were measured using a sliding caliper, and distances between medial and lateral orbital walls were evaluated on paranasal sinus CT scans. The results were compared using Student's t test and Mann-Whitney U test. The distance between medial canthi was found to be significantly increased in nasal polyposis patients compared to controls (P = 0.004). No difference was observed between patients and controls in terms of distances between lateral canthi, medial orbital walls and lateral orbital walls. Anatomic changes regarding orbital morphology may occur in patients with long-standing and advanced nasal polyposis. Early diagnosis and appropriate treatment is of paramount importance in the management of nasal polyposis, since significant anatomic changes leading to orbital dysmorphisms may occur in advanced and long-standing cases. Studies on larger series must be conducted to unveil the morphologic changes and genetic predisposition in nasal polyposis.