DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME AZOLE DERIVATIVES

Basoglu S., Yolal M., Demirci S., DEMİRBAŞ N., Bektas H., Karaoglu S. A.

ACTA POLONIAE PHARMACEUTICA, cilt.70, sa.2, ss.229-236, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 2
  • Basım Tarihi: 2013
  • Dergi Adı: ACTA POLONIAE PHARMACEUTICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.229-236
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Three new 1,3,4-oxadiazole, 1,3-thiazolidine and 1,2,4-triazole derivatives were obtained starting from furan-2-carbohydrazide. Then, 1,2,4-triazole compound was converted to the corresponding Mannich bases using several secondary amines including piperidine, piperazine, morpholine or thiomorpholine moiety. The synthesis of 5-(furan-2-yl)-4-{[(4-methoxyphenyl)methylidene]amino}-4H-1,2,4-triazole-3-thiol (XIII) was performed starting from furan-2-carbohydrazide by three steps. The structures of the synthesized compounds were well characterized by elemental analyses, IR, H-1 NMR, C-13 NMR and mass spectral studies. Newly synthesized compounds were screened for their antimicrobial activities and some of them displayed activity against the tested microorganisms.