SYNTHESIS OF NEW LIGANDS CONTAINING THE SULFONYL GROUP AND ANTIMICROBIAL ACTIVITIES

Gumrukcuoglu N.

JOURNAL OF OPTOELECTRONIC AND BIOMEDICAL MATERIALS, cilt.11, sa.2, ss.29-36, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2019
  • Dergi Adı: JOURNAL OF OPTOELECTRONIC AND BIOMEDICAL MATERIALS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.29-36
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study firstly, the acylhydrazone compound named Ethyl-4-methylbenzene-sulfonylcarbonyl-4-methyl-benzohydrazonate was synthesized by the condensation of ethyl-4methyl-benzimidate hydrochloride with 4-methyl-benzene sulfonyl hydrazide. The treatment of the acylhydrazone compound with hydrazine hydrate afforded 4-amino-3-4-methylbenzene sulfonyl-2-yl-5-4-methyl-phenyl-1, 2, 4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino3-4-methylbenzene sulfonyl-2-yl-5-4-methyl-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-4-methylbenzene sulfonyl-2-yl-5-4-methyl-phenyl-1, 2, 4-triazoles. The obtained products were identified by FT-IR, H-1-NMR, C-13-NMR and elemental analysis data. A series of compounds have been evaluated for their antimicrobial activities. The results show that the synthesized new compounds had effective antimicrobial activities.