In this study firstly, the acylhydrazone compound named Ethyl-4-methylbenzene-sulfonylcarbonyl-4-methyl-benzohydrazonate was synthesized by the condensation of ethyl-4methyl-benzimidate hydrochloride with 4-methyl-benzene sulfonyl hydrazide. The treatment of the acylhydrazone compound with hydrazine hydrate afforded 4-amino-3-4-methylbenzene sulfonyl-2-yl-5-4-methyl-phenyl-1, 2, 4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino3-4-methylbenzene sulfonyl-2-yl-5-4-methyl-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-4-methylbenzene sulfonyl-2-yl-5-4-methyl-phenyl-1, 2, 4-triazoles. The obtained products were identified by FT-IR, H-1-NMR, C-13-NMR and elemental analysis data. A series of compounds have been evaluated for their antimicrobial activities. The results show that the synthesized new compounds had effective antimicrobial activities.