Role of Fanconi anemia/BRCA pathway genes in hepatocellular carcinoma chemoresistance

FERROUDJ S., Yildiz G. , BOURAS M., Iscan E., Ekin U., ÖZTÜRK M.

HEPATOLOGY RESEARCH, vol.46, no.12, pp.1264-1274, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 12
  • Publication Date: 2016
  • Doi Number: 10.1111/hepr.12675
  • Title of Journal : HEPATOLOGY RESEARCH
  • Page Numbers: pp.1264-1274
  • Keywords: BRCA1, chemosensitization, DSB DNA repair, Fanconi anemia, hepatocellular cancer, interstrand cross-linker drugs, MESENCHYMAL TRANSITION, MITOMYCIN-C, DNA-REPAIR, CELL-LINES, RESISTANCE, CANCER, EXPRESSION, BRCA1, SENSITIVITY

Abstract

Aim: To investigate the expression of DNA repair genes and the impact of the breast cancer 1, early onset (BRCA1) protein on chemoresistance of hepatocellular carcinoma (HCC).