Synthesis and antioxidant activities of some 4-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives


YUKSEK H., KOLAYLI S., KUCUK M., YUKSEK M., Ocak U., SAHINBAS E., ...More

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol.45, no.3, pp.715-718, 2006 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 2006
  • Journal Name: INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.715-718
  • Keywords: antioxidant activities, 1,2,4-triazol-5-ones, pK(a) values, 4,5-DIHYDRO-1H-1,2,4-TRIAZOL-5-ONE DERIVATIVES, TITRATIONS

Abstract

Eight 3-alkyl(aryl)-4-(3,4-dihydroxybenzylidenamino)-4,5-dihydro-1/./-1,2,4-triazol-5-ones 2 having 4,5-dihydro-1/./-1,2,4-triazol-5-one ring are synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1/./-1,2,4-triazol-5-ones I with 3,4-dihydroxy-benzaldehyde and their antioxidant activities are investigated. In addition, compounds 2b, 2f and 2h are titrated potentiometrically with tetrabutylammonium hydroxide in non-aqueous solvents and the half neutralization potential values and the corresponding pK(a) values are determined. The structures of new compounds are established from spectral data.