Effects of leptin and insulin on CA III expression in rat adipose tissue

Alver A., Ucar F., Keha E., Kalay E., Ovali E.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.19, no.3, pp.279-281, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1080/14756360410001720445
  • Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.279-281
  • Keywords: leptin, insulin, carbonic anhydrase III, reverse transcriptase-PCR, rat adipose tissue
  • Karadeniz Technical University Affiliated: No

Abstract

Studies on the biochemical and molecular mechanisms underlying obesity have shown that the expression of some proteins was decreased with obesity in rat adipose tissue. One of these proteins is carbonic anhydrase III (CA III) which constitutes 24% of the cytosolic protein content and its function is unclear. A freshly isolated rat adipose cell culture model was used to examine the effect of leptin and insulin on CA III expression. It was found that leptin decreased CA III expression while insulin increased it which suggests that the decrease in CA III expression observed in obesity in rat adipose tissue may be related to hyperleptinemia.