Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

MENTEŞE, Meltem; DEMİRBAŞ, NESLİHAN; MERMER, Arif; Demirci, Serpil; DEMİRBAŞ, AHMET; AYAZ, FAİK

doi:10.2174/1570180814666170823163540

Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

MENTEŞE M., DEMİRBAŞ N., MERMER A., Demirci S., DEMİRBAŞ A., AYAZ F. A.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.1, ss.46-64, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 1
Basım Tarihi: 2018
Doi Numarası: 10.2174/1570180814666170823163540
Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.46-64
Anahtar Kelimeler: Fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole, piperazine, antibacterial activity, antioxidant activity, microwave, BIOLOGICAL-ACTIVITIES, DNA GYRASE, ASSISTED SYNTHESIS, 1,2,4-TRIAZOLE-CIPROFLOXACIN HYBRIDS, ANTIMICROBIAL ACTIVITIES, ATPASE INHIBITORS, PENICILLANIC ACID, DERIVATIVES, FLUOROQUINOLONES, MOLECULES
Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques.