Acute effects of grayanotoxin in rhododendron honey on kidney functions in rats


Silici S., Dogan Z., Sahin H., Atayoglu T., Yakan B.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, vol.23, no.4, pp.3300-3309, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1007/s11356-015-5534-z
  • Title of Journal : ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Page Numbers: pp.3300-3309

Abstract

The aim of the study is to evaluate the acute biochemical and histological changes in rat kidneys after treatment with grayanotoxin (GTX) of rhododendron honey (RH). A total of 60 Sprague-Dawley female rats were divided into five groups of 12 rats each, one being a control group (group 1) and group 2 was treated with 0.015 mg/kg/bw of GTX standard preparation via intraperitoneal injection. Groups 3, 4, and 5 were given RH at doses of 0.1, 0.5, and 2.5 g/kg/bw, respectively, via oral gavage. Compared to the control group, significant increases were observed in glucose, blood urea nitrogen (BUN), and creatinine levels of the GTX-injected groups after 1 h. However, in low dose RH group, such an increase was not observed and had a normal appearance histologically. Therefore, low dose (1 g/kg/bw) of RH produces no acute adverse effects on renal functions of rats.