Safety of azathioprine and methylprednisolone during breastfeeding: a case report
NEUROTOXICOLOGY AND TERATOLOGY, vol.109, no.0, pp.31-32, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Abstract
- Volume: 109 Issue: 0
- Publication Date: 2025
- Doi Number: 10.1016/j.ntt.2025.107515
- Journal Name: NEUROTOXICOLOGY AND TERATOLOGY
- Journal Indexes: Scopus, Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, Chemical Abstracts Core, EMBASE, Environment Index, MEDLINE, Psycinfo
- Page Numbers: pp.31-32
- Karadeniz Technical University Affiliated: Yes
Abstract
Introduction Autoimmune hepatitis (aih) is a chronic inflammatory disease of the liver that can cause necrosis and fibrosis due to increased circulating auto-antibodies (such as antinuclear antibodies, anti-smooth muscle antibodies). It is mostly seen in women and patients may present in a wide spectrum from asymptomatic to acute liver failure. Aih treatment is started with 40–60 mg oral glucocorticoid daily. Subsequently, the glucocorticoid dose is reduced and antimetabolite agents (thiopurines or mycophenolate) are added to the treatment. According to current literature data, the use of glucocorticoids and thiopurines in pregnant and lactating women appears to be safe.