IL-17A, MCP-1, CCR-2, and ABCA1 polymorphisms in children with non-alcoholic fatty liver disease

Akbulut U. E., EMEKSİZ H. C., Citli S., ÇEBİ A. H., Korkmaz H. A., Baki G.

JORNAL DE PEDIATRIA, no.3, pp.350-357, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jped.2018.03.005
  • Journal Name: JORNAL DE PEDIATRIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.350-357
  • Keywords: Liver disease, Single-nucleotide polymorphisms, Obesity, Children, Interleukin-17, REGULATORY T-CELLS, PEDIATRIC GASTROENTEROLOGY, RHEUMATOID-ARTHRITIS, KOREAN PATIENTS, GENE, STEATOHEPATITIS, SUSCEPTIBILITY, ASSOCIATION, POPULATION
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objective: The prevalence of non-alcoholic fatty liver disease in children has risen significantly, owing to the worldwide childhood obesity epidemic in the last two decades. Non-alcoholic fatty liver disease is closely linked to sedentary lifestyle, increased body mass index, and visceral adiposity. In addition, individual genetic variations also have a role in the development and progression of non-alcoholic fatty liver disease. The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease. Methods: The study recruited 186 obese children aged 10-17 years, including 101 children with non-alcoholic fatty liver disease and 85 children without non-alcoholic fatty liver disease. Anthropometric measurements, insulin resistance, a liver panel, a lipid profile, liver ultrasound examination, and genotyping of the four variants were performed. Results: No difference was found between the groups in respect to age and gender, body mass index, waist/hip ratio, or body fat ratio. In addition to the elevated ALT levels, AST and GGT levels were found significantly higher in the non-alcoholic fatty liver disease group compared to the non non-alcoholic fatty liver disease group (p< 0.05). The A-allele of IL-17A (-197 G/A) (rs2275913) was associated with non-alcoholic fatty liver disease (odds ratio [OR] 2.05, 95% confidence interval: 1.12-3.77, p= 0.02). Conclusions: The findings of this study suggest that there may be an association between IL-17A (-197 G/A) (rs2275913) polymorphism and non-alcoholic fatty liver disease development in obese Turkish children. (C) 2018 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.