Circulating parameters of oxidative stress and hypoxia in normal pregnancy and HELLP syndrome

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MENTEŞE A., GÜVEN S., DEMİR S., Sumer A., YAMAN S. O., ALVER A., ...More

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.27, no.11, pp.1567-1572, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.17219/acem/74653
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1567-1572
  • Keywords: oxidative stress, carbonic anhydrases, hypoxia, HELLP syndrome, CARBONIC-ANHYDRASE-IX, MARKERS
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background. The HELLP syndrome (Hemolysis, Elevated Liver enzymes and Low Platelets) is a complication of severe pre-eclampsia, a condition characterized by oxidative stress elevation caused by disequilibrium between lipid peroxidation and antioxidant defense mechanisms, which, in turn, results in endothelial compromise and free radical-mediated cell damage. While several studies have examined the relationship between pre-eclampsia and oxidative stress, research investigating oxidative and hypoxic status in HELLP syndrome is limited.