Circulating parameters of oxidative stress and hypoxia in normal pregnancy and HELLP syndrome


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MENTEŞE A. , GÜVEN S. , DEMİR S. , Sumer A., YAMAN S. O. , ALVER A. , ...More

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.27, no.11, pp.1567-1572, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 11
  • Publication Date: 2018
  • Doi Number: 10.17219/acem/74653
  • Title of Journal : ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Page Numbers: pp.1567-1572
  • Keywords: oxidative stress, carbonic anhydrases, hypoxia, HELLP syndrome, CARBONIC-ANHYDRASE-IX, MARKERS

Abstract

Background. The HELLP syndrome (Hemolysis, Elevated Liver enzymes and Low Platelets) is a complication of severe pre-eclampsia, a condition characterized by oxidative stress elevation caused by disequilibrium between lipid peroxidation and antioxidant defense mechanisms, which, in turn, results in endothelial compromise and free radical-mediated cell damage. While several studies have examined the relationship between pre-eclampsia and oxidative stress, research investigating oxidative and hypoxic status in HELLP syndrome is limited.