We calculate the contribution of the higher-twist Feynman diagrams to the large-p(T) inclusive pion production cross section in proton-proton collisions in the cases of the running and frozen coupling approaches within holographic QCD. The structure of the infrared renormalon singularities of the higher-twist subprocess cross section and its resummed expression are found. We compare the resummed higher-twist cross sections with the ones obtained in the framework of the frozen coupling approximation and the leading-twist cross section. We discuss the phenomenological consequences of possible higher-twist contributions to the pion production in proton-proton collisions within holographic QCD. (C) 2012 Elsevier Inc. All rights reserved.