Alpha-Lipoic Acid and Cyanocobalamin Co-Loaded Nanoemulsions: Development, Characterization, and Evaluation of Stability

ÇOBAN Ö., YILDIRIM S., Bakir T.

JOURNAL OF PHARMACEUTICAL INNOVATION, vol.17, no.2, pp.510-520, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1007/s12247-020-09531-4
  • Journal Name: JOURNAL OF PHARMACEUTICAL INNOVATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, INSPEC
  • Page Numbers: pp.510-520
  • Keywords: Alpha-lipoic acid, Cyanocobalamin, Nanoemulsion, Solvent evaporation method, HPLC, CASTOR-OIL, IN-VITRO, WATER, RELEASE, CARRIER, BIOAVAILABILITY, CELLS, HOMOGENIZATION, VITAMIN-B-12, PROTECTS
  • Karadeniz Technical University Affiliated: Yes

Abstract

Purpose This study aimed to prepare a suitable formulation and perform in vitro characterization studies for oral use by exploiting the synergistic effect of alpha-lipoic acid (ALA) and cyanocobalamin (Vit B-12) for the treatment and prophylaxis of various diseases such as diabetic neuropathy, peripheral neuropathy, and neurological disorders.