Alpha-Lipoic Acid and Cyanocobalamin Co-Loaded Nanoemulsions: Development, Characterization, and Evaluation of Stability

ÇOBAN Ö., YILDIRIM S., Bakir T.

JOURNAL OF PHARMACEUTICAL INNOVATION, cilt.17, sa.2, ss.510-520, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s12247-020-09531-4
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL INNOVATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, INSPEC
  • Sayfa Sayıları: ss.510-520
  • Anahtar Kelimeler: Alpha-lipoic acid, Cyanocobalamin, Nanoemulsion, Solvent evaporation method, HPLC, CASTOR-OIL, IN-VITRO, WATER, RELEASE, CARRIER, BIOAVAILABILITY, CELLS, HOMOGENIZATION, VITAMIN-B-12, PROTECTS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Purpose This study aimed to prepare a suitable formulation and perform in vitro characterization studies for oral use by exploiting the synergistic effect of alpha-lipoic acid (ALA) and cyanocobalamin (Vit B-12) for the treatment and prophylaxis of various diseases such as diabetic neuropathy, peripheral neuropathy, and neurological disorders.