Delayed respiratory depression after risperidone overdose

AKYOL A., SENEL A. C., Ulusoy H., KARIP F., ERCIYES N.

ANESTHESIA AND ANALGESIA, cilt.101, sa.5, ss.1490-1491, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1213/01.ane.0000180195.57760.e9
  • Dergi Adı: ANESTHESIA AND ANALGESIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1490-1491
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Risperidone is an atypical antipsychotic drug used for the treatment of schizophrenia. Both positive and negative symptoms are prominent with its use. Metabolism occurs mainly in the liver, where risperidone is changed by CUP2D6 to an active metabolite, 9-hydroxyrisperidone. The half-lives of risperidone and its metabolite are 3 and 7 h, respectively. Genetic polymorphism is seen in the 6%-8% of white patients who are considered poor metabolizers. In poor metabolizers, the half-life extends to 20-30 h. We present an unusual case of unanticipated delayed respiratory depression after risperidone overdose.