The effects of ascorbic acid on penicillin-induced epileptiform activity in rats

AYYILDIZ M., COSKUN S., Yildirim M., AGAR E.

EPILEPSIA, vol.48, no.7, pp.1388-1395, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 7
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1528-1167.2007.01080.x
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1388-1395
  • Karadeniz Technical University Affiliated: No

Abstract

Purpose: Epileptic seizure results from excessive discharge in a population of hyperexcitable neurons. A number of studies help to document the effects of active oxygen free radical scavengers such as alpha-tocopherol or ascorbic acid (vitamin C). In the present study, we examined the effects of ascorbic acid, at the six different doses, on penicillin-induced epileptiform activity.