Synthesis and anticancer evaluation of some new unsymmetrical 3,5-diaryl-4H-1,2,4-triazole derivatives

Berikrcan O., Kahveci B., Küçük M.

TURKISH JOURNAL OF CHEMISTRY, cilt.30, sa.1, ss.29-40, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2006
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.29-40
  • Anahtar Kelimeler: 4H-1,2,4-triazoles, 4-amino-4H-1,2,4-triazoles, 4-arylidenamino-4H-1,2,4-triazoles, 4-arylmethylenamino-4H-1,2,4-triazoles, synthesis, anticancer activity, NATIONAL-CANCER-INSTITUTE, 3,5-DISUBSTITUTED 4-AMINO-1,2,4-TRIAZOLES, MILD-STEEL, ANTITUMOR AGENTS, DRUG DISCOVERY, HCL MEDIUM, 3,5-DISUBSTITUTED-4-AMINO-1,2,4-TRIAZOLES, ANTIBACTERIAL, CORROSION, MICROWAVE
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

A series of 4-arylidenamino-4H-1,2,4-triazole derivatives (3-11) were synthesized from the treatment of 4-amino-4H-1,2,4-triazoles (2) with certain aldehydes. Compounds 3-11 were reduced with NaBH4 to afford the corresponding 4-arylmethylenamino-4H-1,2,4-triazoles (12-20). Compounds 1-10 and 12-19 were characterized by elemental analyses and H-1 NMR, C-13 NMR, IR, and UV spectral data. Compounds 11 and 20 were characterized by H-1 NMR, C-13 NMR, IR and mass spectral data. Compounds 14, 16, 17, and 18 were tested for anticancer activities. Compound 17, chosen for its higher anticancer activity in the preliminary tests with the cancer cell lines of MCF7, NCI-H460, and SF-268, exhibited remarkable anticancer potential in screening tests with 60 human cancer cell lines.