9th International Congress of Drug Chemistry: Design, Synthesis, Production and Standardization of Pharmaceutical Active Substances, Antalya, Turkey, 08 April 2021
Terpenoids are unique scaffold that might be used for further chemical modification aimed at
synthesizing the compounds simultaneously affecting the central and peripheral nervous systems.
Bearing this idea in mind, a series of terpenoid derivatives were designed and synthesized as potential
analgesic and anticonvulsant agents that may additionally enhance the skin permeability. The
structure of terpenoid derivatives was characterized by 13C-NMR, 1H-NMR, FTIR-ATR, Ramanspectroscopy and ESI-mass spectrometry. All compounds have been synthesized and purified up to
99% purity confirmed by high-performance liquid chromatography (HPLC); thermal behavior of
terpenoid derivatives was performed by differential scanning calorimetry (DSC).