Large-scale instability phenomena frequently occur in slopes in such geologically complex areas as Dogankent in NE Turkey. This study presents an application of the interaction matrices (IM) methodology, as a semi-qualitative method sensitive to large-scale slope instability. For both rock and soil slopes, the main interactive factors were distance from faults, degree of weathering and slope angle. Using IM, a slope failure susceptibility map was created for the Dogankent area and checked again field evidence. The results indicated that IM could be a useful method for slope stability assessment.