Bioimaging of thiazolidine-4-one-based new probes, fluorimetric detection of Cu<SUP>2+</SUP> "<i>on</i>-<i>off</i>" sensor property, DFT calculation, molecular docking studies, and multiple real samples application

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Atıf İçin Kopyala

Karakilic E., Basceken S., Eskiler G. G., UZUNER U., Baran A.

FOOD CHEMISTRY, cilt.463, 2025 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 463
• Basım Tarihi: 2025
• Doi Numarası: 10.1016/j.foodchem.2024.141269
• Dergi Adı: FOOD CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
• Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Thiazolidinones have been the subject of various research areas for their biological activities, thus they were promising scaffolds to develop new drug agents. A novel thiazolidine 4-one-based fluorescent chemosensor probes PS (thiazolidine) and BO (oxazolidine) were designed and synthesized. Both probes showed specific recognition against Cu2+ via a "turn-off" fluorescence response in ACN/H2O (v/v: 50/50) stock solution (10 mM, pH = 7.0) with a detection limit of (for BO: 1.9 nM and PS: 1.03 nM). Finally, the detection of chemosensory PS and BO showed positive potential for the determination of Cu2+ in real food samples, drinking water, and mung beans. The compounds were characterized by diferent chemical and spectroscopic methods. The proposed binding mode for PS and BO with Cu2+ was confirmed by DFT calculation, and also they elucidated by bioimaging studies against MCF-7 live cell lines. Additionally, the docking experiment was performed on XylE and hAChE targets.