Oxidative stress and neurocognitive function in patients with autogenous and reactive type OCD

Karaguzel E., Arslan F. C., DEMİR S., Aykut D. S., Demirtas Y., KARAHAN S. C.

KLINIK PSIKIYATRI DERGISI-TURKISH JOURNAL OF CLINICAL PSYCHIATRY, vol.25, no.1, pp.15-22, 2022 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.5505/kpd.2022.37431
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Psycinfo, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.15-22
  • Keywords: Obsessive compulsive disorder, Oxidative stress, cognition, Autogenous obsessions, Reactive obsessions, cognitive dysfunction, OBSESSIVE-COMPULSIVE DISORDER, MEMORY, DAMAGE, METACOGNITIONS, QUESTIONNAIRE, RELIABILITY, VALIDITY, ANXIETY, MARKERS
  • Karadeniz Technical University Affiliated: Yes


Objective: The number of studies investigating oxidative stress levels in OCD subtypes is limited. This study aimed to compared total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index values between OCD subtypes and to determine relationship between oxidative stress and neurocognitive function. Method: T19 autogenous type OCD, 21 reactive type OCD and 42 healthy controls were taken to this study.All patients were rated using the Yale-Brown Obsessive Compulsive Scale, the Metacognition Questionnaire, the Beck Depression Inventory and Beck Anxiety Inventory, the Wisconsin Card Sorting Test, and the Stroop test. Serum TOS and TAS levels were determined. Results: TAS levels were significantly higher in patients with OCD (p=0.018) than in the healthy controls. TAS levels were also significantly higher in patients with RT type OCD than in the healthy controls (p=0.003). In RT OCD, TAS was correlated with the Wisconsin Card Sorting Test - trials to complete the first category (p=0.02) and the Metacognition Questionnaire need to control thoughts (p=0.02) sub scales. Discussion: The study findings indicated an overall oxidative imbalance shift toward the antioxidant side in patients with OCD and RT type OCD. This may be a way of coping with the disease. The correlation between TAS and the Wisconsin Card Sorting Test - trials to complete the first category subscale suggests that the change in serum TAS level may be a condition that for overcoming mental inflexibility. These results should be confirmed by prospective studies.