Background. The chronic recommendation of pediatric drugs could exhibit erosive and cariogenic problems. Objective. To evaluate the effects of different pediatric drugs on the color stability of various restorative materials. Methods. Five specimens (1mm x 3 mm) were prepared and immersed in ten different pediatric drugs and agitated every 8 hours daily for 2 min up to 1 week. Between immersion periods, the samples were stored in artificial saliva. After 1-week period, Delta Epsilon(*) values were calculated. Two-way ANOVA and Fisher's LSD test were used for statistical analysis at a level of p< 0.05. Results. Delta Epsilon(*) values were only significantly influenced by restorative material factor (p< 0.001) and varied in the range of 2.08 and 6.55 units for all drugs/estorative materials. The highest Delta Epsilon(*) was found in Ferrosanol B-composite (6.55 +/- 1.38) and the lowestonewas found inDolven-glass ionomer (2.08 +/- 0.40) pairwise. The most prominent Delta Epsilon(*) value elevations were obtained in composite material compared to the compomer and/or glass ionomers inMacrol, Ferrosanol B, and Ventolin (p < 0.001; for all) and also for other drugs (p< 0.05). Dolven exhibited significantly higher values compared to Augmentin (p - 0.021), Macrol (p - 0.018), and Ventolin (p - 0.013) in compomer group. Conclusion. The clinically perceptible color changes for tested composite/pediatric drug pairwise can be more problematic than compomer and glass ionomers in pediatric dentistry.