Synthesis and antimicrobial activity of some 3-alkyl-4-(arylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones


Kahveci B. , Bekircan O. , Karaoğlu Ş. A.

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol.44, no.12, pp.2614-2617, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 12
  • Publication Date: 2005
  • Title of Journal : INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
  • Page Numbers: pp.2614-2617

Abstract

Eight new ethyl N'-(3-methyl-4-arylmethyleneamino-4,5-dihydro-1H-1,2,4-triazolyl-5-one)acetates 2 and N'-(3-methyl-4-arylmethyleneamino-4,5-dihydro-1H-1,2,4-triazolyl-5-one)acetyl-hydrazines 3 have been synthesized. The structures of the compounds have been confirmed by IR and H-1 NMR spectra and microanalysis. The compounds show some antimicrobial activities. Compound 2a shows antibacterial activity against B. subtilis. Compounds 3a, 3b and 3d have antifungal activity against Candida species.