Synthesis of 1,2,4-triazole-5-on derivatives and determination of carbonic anhydrase II isoenzyme inhibition effects


AKIN S., AYALOGLU H., GULTEKIN E., ÇOLAK A. , BEKİRCAN O. , Akatin M. Y.

Bioorganic Chemistry, vol.83, pp.170-179, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bioorg.2018.10.042
  • Title of Journal : Bioorganic Chemistry
  • Page Numbers: pp.170-179
  • Keywords: 1,2,4-Triazoles, Carbonic anhydrase, Inhibition, Molecular docking, Uncompetitive, ADME properties, ISOZYME-II, BIOLOGICAL EVALUATION, CRYSTAL-STRUCTURE, DRUG DISCOVERY, X-RAY, SULFONAMIDES, TARGET, IX, TRANSMEMBRANE, DOCKING