Copy For Citation
Demir S., Türkmen Alemdar N., Ayazoğlu Demir E., Menteşe A., Aliyazıcıoğlu Y.
Farabi Medical Journal, vol.3, no.2, pp.57-62, 2024 (Peer-Reviewed Journal)
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Publication Type:
Article / Article
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Volume:
3
Issue:
2
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Publication Date:
2024
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Doi Number:
10.59518/farabimedj.1484155
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Journal Name:
Farabi Medical Journal
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Journal Indexes:
Other Indexes
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Page Numbers:
pp.57-62
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Karadeniz Technical University Affiliated:
Yes
Abstract
The use of methotrexate (MTX), a chemotherapy agent, is limited by a number of side effects, including pulmonary toxicity. Oxidative stress (OS) and inflammation are possible mechanisms of MTX-associated pulmonary toxicity. p-Coumaric acid (PCA) is a phenolic acid that has been demonstrated to exert a number of beneficial effects on human health, particularly in relation to antioxidant and anti-inflammatory activity. The potential effects of PCA in reducing MTX-induced pulmonary toxicity were investigated in the current study. After MTX (20 mg/kg) was administered to the rats on day 1, two different doses of PCA (2 and 4 mg/kg) were administered intraperitoneally for 3 days and the levels of OS, inflammation and apoptosis were assessed in the lung tissues collected on day 5. PCA applications largely eliminated MTX-induced OS, inflammation and apoptosis in lung tissue via enhancing the capacity of endogenous antioxidant system. The therapeutic effect of PCA against MTX-induced pulmonary toxicity should be re-evaluated in more systematic studies.