The Therapeutic Effect of p-Coumaric Acid on Lung Toxicity Induced by Methotrexate in Rats


Demir S., Türkmen Alemdar N., Ayazoğlu Demir E., Menteşe A., Aliyazıcıoğlu Y.

Farabi Medical Journal, cilt.3, sa.2, ss.57-62, 2024 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.59518/farabimedj.1484155
  • Dergi Adı: Farabi Medical Journal
  • Derginin Tarandığı İndeksler: Other Indexes
  • Sayfa Sayıları: ss.57-62
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

The use of methotrexate (MTX), a chemotherapy agent, is limited by a number of side effects, including pulmonary toxicity. Oxidative stress (OS) and inflammation are possible mechanisms of MTX-associated pulmonary toxicity. p-Coumaric acid (PCA) is a phenolic acid that has been demonstrated to exert a number of beneficial effects on human health, particularly in relation to antioxidant and anti-inflammatory activity. The potential effects of PCA in reducing MTX-induced pulmonary toxicity were investigated in the current study. After MTX (20 mg/kg) was administered to the rats on day 1, two different doses of PCA (2 and 4 mg/kg) were administered intraperitoneally for 3 days and the levels of OS, inflammation and apoptosis were assessed in the lung tissues collected on day 5. PCA applications largely eliminated MTX-induced OS, inflammation and apoptosis in lung tissue via enhancing the capacity of endogenous antioxidant system. The therapeutic effect of PCA against MTX-induced pulmonary toxicity should be re-evaluated in more systematic studies.