Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro

Ulukaya E., ARI F., Dimas K., SARIMAHMUT M., Guney E., Sakellaridis N., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.137, sa.10, ss.1425-1434, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 137 Sayı: 10
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00432-011-1021-1
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1425-1434
  • Anahtar Kelimeler: Lung cancer treatment, Palladium(II) and platinum(II) complexes, Necrosis, CYTOTOXIC ACTIVITY, CRYSTAL-STRUCTURE, ANTITUMOR AGENTS, CISPLATIN, PD(II), DNA, APOPTOSIS, PT(II), ASSAY, HEPATOTOXICITY
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex 1), [Pt(sac)(terpy)] (sac).5H(2)O (Complex 2), [PdCl(terpy)](sac).2H(2)O (Complex 3), [PtCl(terpy)](sac).2H(2)O (Complex 4)} have been tested against three different non-small cell lung cancer cell lines (A549, H1299, PC-3).