The aim of this study was to determine effect of different teaching methods and techniques embedded within 5E model on grade 8th students alternative conceptions of "fluid pressure." The sample comprised of 48 8th grade students (experimental group, N = 25; control group, N = 23). Quasi-experimental research design is used in this study. An questionnaire with three two-tier items was employed to collect data. Teaching material based on the 5E Instructional Model enriched with various teaching methods and techniques is used in the experimental group. The control group is taught in a conventional way by using course textbook, in brief chalk and talk. The results showed that the instructional material prepared for this study has differentiated the conceptual structures in a desired way and promoted conceptual change.