Prolonged Immunosuppressive Therapy in Immune Complex-Membranoproliferative Glomerulonephritis: A Case Report of Sustained Partial Remission Over Three Years

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Kaynar R. K., Dilek Y., Köse M., Mungan S. A.

ASIDE Internal Medicine, vol.2, no.2, pp.16-20, 2025 (Peer-Reviewed Journal)

• Publication Type: Article / Case Report
• Volume: 2 Issue: 2
• Publication Date: 2025
• Doi Number: 10.71079/aside.im.090425144
• Journal Name: ASIDE Internal Medicine
• Page Numbers: pp.16-20
• Karadeniz Technical University Affiliated: Yes

Abstract

The prevalence of membranoproliferative glomerulonephritis (MPGN) is very low among primary glomerulonephritis. Once MPGN is diagnosed, it is essential to classify the type of MPGN [immune complex (IC), complement-mediated, and without complement or IC deposition]. In cases of IC-MPGN, secondary causes should be thoroughly investigated. However, there are no randomised controlled prospective trials for the optimal treatment regime for primary IC-MPGN. Here, we present a report of primary IC-MPGN that achieved partial remission after 3 years of mycophenolate mofetil treatment, even though significant fibrosis was present in the kidney biopsy. This report may support consideration of prolonged immunosuppression in selected cases with primary IC-MPGN.