Synthesis of a new 1,2,3,4,5-pentasubstituted cyclohexanol and determining its stereochemistry by NMR spectroscopy and quantum-chemical calculations

MAMEDOV I., Abbasoglu R., BAYRAMOV M., MAHARRAMOV A.

MAGNETIC RESONANCE IN CHEMISTRY, vol.54, no.4, pp.315-319, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1002/mrc.4377
  • Journal Name: MAGNETIC RESONANCE IN CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.315-319
  • Karadeniz Technical University Affiliated: Yes

Abstract

The presence of substituents in cyclohexane can influence to the ratio of conformers; for some cases, the boat form is preferable. The new six-membered cyclohexanol derivative 2 has been obtained by the synthesis of (E)-1-(bromophenyl)-3-phenylpropen-2-one (1). The NMR and quantum-chemical conformational analysis for the 2 have carried out, and its possible mechanism of formation was given. Copyright (c) 2015 John Wiley & Sons, Ltd.