Within-Day Variability in Key Assessment of SpondyloArthritis International Society Outcomes in Axial Spondyloarthritis
Archives of Rheumatology, cilt.41, sa.4, ss.434-441, 2026 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.5152/archrheumatol.2026.25286
- Dergi Adı: Archives of Rheumatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.434-441
- Anahtar Kelimeler: Ankylosing spondylitis, axial spondyloarthritis, diurnal variation, inflammatory rheumatic disorders
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
Background/Aims: This study aimed to investigate within-day variability in pain, stiffness, disease activity, physical function, spinal mobility, and other clinical outcomes in axial spondyloarthritis (axSpA) and identify predictors of within-day improvement. Materials and Methods: In this single-center cross-sectional study, patients with axSpA underwent 2 standardized clinical evaluations on the same day: a morning session (9:00-10:00 am) and an afternoon session (2:00-3:00 pm). Assessments included the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score incorporating C-reactive protein (ASDAS-CRP), Bath Ankylosing Spondylitis Metrology Index (BASMI), Ankylosing Spondylitis Quality of Life (ASQoL), Bath Ankylosing Spondylitis Functional Index (BASFI). Hip internal/external rotation range of motion was assessed using a goniometer, and chest expansion was measured using standardized methods. Multivariate logistic regression identified predictors of within-day improvement. Results: Eighty patients with axSpA were included (mean age 44.3 ± 12.4 years; 63.7% male). Significant within-day improvements were observed in pain (P = .015) morning stiffness (P = .001), BASFI (P = .013), BASMI (P = .001), and ASQoL (P = .006), chest expansion (P = .032), and hip internal/external rotation (P = .005, P = .036, respectively) in the afternoon, whereas BASDAI and ASDAS-CRP remained stable. Higher morning BASDAI and lower body mass index independently predicted within-day improvement in BASFI. Non-smoking status was a strong predictor of ASQoL improvement. Conclusion: Clinically meaningful within-day variability exists in key clinical parameters and patient-reported outcomes in axSpA. Assessment timing significantly influences outcome interpretation and should be standardized in both clinical practice and research to enhance reliability and comparability.