Seasonal Variation of Relapse Rate in Multiple Sclerosis is Latitude Dependent

Spelman, Tim; Gray, Orla; Trojano, Maria; Petersen, Thor; Izquierdo, Guillermo; Lugaresi, Alessandra; Hupperts, Raymond; Bergamaschi, Roberto; Duquette, Pierre; Grammond, Pierre; Giuliani, Giorgio; BOZ, CAVİT; Verheul, Freek; Oreja-Guevara, Celia; Barnett, Michael; Grand'Maison, Francois; Rio, Maria; Lechner-Scott, Jeannette; Van Pesch, Vincent; Fernandez Bolanos, Ricardo; Flechter, Shlomo; Den Braber-Moerland, Leontien; Iuliano, Gerardo; Amato, Maria; Slee, Mark; Cristiano, Edgardo; Laura Saladino, Maria; Paine, Mark; Vella, Norbert; Kasa, Krisztian; Deri, Norma; Herbert, Joseph; Moore, Fraser; Petkovska-Boskova, Tatjana; Alroughani, Raed; Savino, Aldo; Shaw, Cameron; Vucic, Steve; Santiago, Vetere; Alejandra Bacile, Elizabeth; Skromne, Eli; Poehlau, Dieter; Antonio Cabrera-Gomez, Jose; Lucas, Robyn; Butzkueven, Helmut

doi:10.1002/ana.24287

Seasonal Variation of Relapse Rate in Multiple Sclerosis is Latitude Dependent

Spelman T., Gray O., Trojano M., Petersen T., Izquierdo G., Lugaresi A., ...More

ANNALS OF NEUROLOGY, vol.76, no.6, pp.880-890, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 76 Issue: 6
Publication Date: 2014
Doi Number: 10.1002/ana.24287
Journal Name: ANNALS OF NEUROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.880-890
Karadeniz Technical University Affiliated: Yes

Abstract

ObjectivePrevious studies assessing seasonal variation of relapse onset in multiple sclerosis have had conflicting results. Small relapse numbers, differing diagnostic criteria, and single region studies limit the generalizability of prior results. The aim of this study was to determine whether there is a temporal variation in onset of relapses in both hemispheres and to determine whether seasonal peak relapse probability varies with latitude.