Seasonal Variation of Relapse Rate in Multiple Sclerosis is Latitude Dependent

Spelman T., Gray O., Trojano M., Petersen T., Izquierdo G., Lugaresi A., ...More

ANNALS OF NEUROLOGY, vol.76, no.6, pp.880-890, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1002/ana.24287
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.880-890
  • Karadeniz Technical University Affiliated: Yes


ObjectivePrevious studies assessing seasonal variation of relapse onset in multiple sclerosis have had conflicting results. Small relapse numbers, differing diagnostic criteria, and single region studies limit the generalizability of prior results. The aim of this study was to determine whether there is a temporal variation in onset of relapses in both hemispheres and to determine whether seasonal peak relapse probability varies with latitude.