Akademik Veri Yönetim Sistemi
EUFEPS - SITELF Meeting 2026, Naples, İtalya, 27 - 29 Mayıs 2026, ss.1, (Özet Bildiri)
Bedsores (also known as pressure sores or pressure ulcers) are localized injuries to the skin and underlying tissues caused by prolonged pressure. If left untreated, they can significantly reduce quality of life, prolong the healing process, and increase mortality risk, especially in critically ill patients [1].
The aim of this study was to develop and characterize Mupirocin Calcium (MC)-loaded wound dressings with antibacterial effects for the treatment of bedsore. The physicochemical properties of the active ingredient and polymers were confirmed by DSC and FTIR analyses. A validated HPLC method was developed for the quantification of MC. The viscosity, surface tension, and electrical conductivity of the polymer solutions were investigated to optimize the electrospinning process.
Morphological examination of the nanofibers revealed fiber diameters ranging from 232 nm to 789 nm with high porosity (49-61%). The developed nanofibers possessed the necessary mechanical strength and flexibility required for pressure ulcer treatment. While MC-free PCL nanofibers exhibited hydrophobic characteristics, the hydrophilic nature of the MC reduced the contact angle to 0° in all drug-loaded formulations, resulting in a fully wettable surface. In vitro release studies demonstrated that the cumulative release of MC from the developed formulations ranged between approximately 79% and 93% at the end of the 8-hour period. Mathematical modeling using DDSolver confirmed that the MC release profile was consistent with First-Order kinetics. Furthermore, ex vivo skin permeation studies demonstrated higher MC retention in the skin for PCL-based nanofibers compared to CA-based formulations, providing a significant advantage for localized treatment. The high porosity and mechanical integrity of these nanofibers facilitate adaptation to the wound site. When combined with high wettability, these properties support rapid interaction with wound fluid, enabling an effective topical therapeutic approach.