Tocolytic effect of parecoxib, a new parenteral cyclo-oxygenase-2-specific inhibitor, on the spontaneous and prostaglandin-induced contractions of rat isolated myometrium


AYAR A.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.34, no.8, pp.737-741, 2007 (Journal Indexed in SCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1440-1681.2007.04632.x
  • Title of Journal : CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Page Numbers: pp.737-741
  • Keywords: contractility, cyclo-oxygenase 2 inhibitors, myometrium, parecoxib, prostaglandin F-2 alpha, rat, CYCLOOXYGENASE-2 INHIBITOR, COX-2 INHIBITORS, IN-VITRO, EXPRESSION

Abstract

1. The present study was undertaken to elucidate the effects of parecoxib, a novel cyclo-oxygenase (COX)-2 inhibitor, on spontaneous and prostaglandin-induced contractions of uterine smooth muscle.