Association between skeletal muscle changes, anthropometric measurements, and clinical outcomes in critically ill trauma and surgical patients: A prospective observational study.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, vol.37, no.6, pp.1326-1335, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 37 Issue: 6
- Publication Date: 2022
- Doi Number: 10.1002/ncp.10865
- Journal Name: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
- Page Numbers: pp.1326-1335
- Keywords: anthropometric measurements, clinical outcomes, critical illness, intensive care unit, muscle loss, nutrition status, ultrasound, SUBJECTIVE GLOBAL ASSESSMENT, ULTRASOUND MEASUREMENT, NUTRITIONAL ASSESSMENT, BEDSIDE ULTRASOUND, ASSESSMENT-TOOL, FRAILTY, AREA, MASS, CARE
- Karadeniz Technical University Affiliated: Yes
Abstract
Background Acute skeletal muscle wasting may predict clinical outcomes in critically ill patients. This study aimed to assess acute muscle loss, changes in anthropometric measurements, and the relationship between muscle loss and clinical outcomes in critically ill trauma and surgical patients. Methods This single-center, prospective observational study was conducted in critically ill trauma and surgical patients who were expected to stay in the intensive care unit (ICU) for at least 7 days. Rectus femoris cross-sectional area muscle measurements were performed by bedside ultrasound, and anthropometric measurements were obtained at baseline and 7 days after the first assessment. Length of mechanical ventilation, ICU and hospital stay, and mortality were recorded. Results Thirty-five patients with a mean age of 49.6 +/- 18.6 years and 74.1% male were enrolled. The rectus femoris cross-sectional area, mid-arm circumference, and calf circumference were reduced at second assessment from baseline (P < 0.05). In univariate analysis, muscle loss and changes in anthropometric measurements were not associated with 90-day mortality (P > 0.05). Conclusion Muscle loss in critical trauma and surgical patients occurred rapidly during the first week of critical illness. Rectus femoris muscle cross-sectional area assessment can be used to detect skeletal muscle changes in critically ill patients. Further investigations on the skeletal muscle changes and clinical outcomes need to be conducted.